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1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

Release time:2023-07-01

Product Name: 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
Alias: DMG-PEG 2000; DMG-mPEG2000; mPEG-DMG-2K; mPEG-DMG-2000; DMG-PEG; DMG-PEG2K; DMG-PEG2000; Methoxypoly(ethylene glycol) dimyristoyl glycerol; Methoxypoly(ethylene glycol) dimyristoyl glycerol-2K; Methoxypoly(ethylene glycol) dimyristoyl glycerol-2000; Polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG]; 1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol 2000; 1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol
CAS No.: 160743-62-4
Molecular Formula: (C2H4O)nC32H62O5
Molecular Weight: 2000, 5000, 10000, 20000, 30000, 40000


Specifications of our 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000(DMG-PEG2000):

Test Items Specifications Test Methods
Appearance White powder-like solid Visual
Identity
IR Complies with the reference substance structure IR
H-NMR Complies with the reference substance structure
H-NMR
Average molecular weight 2500±200 Da MALDI-TOF
Assay 90.0% ~ 110.0% HPLC-CAD
Purity
Not less than 95.0% HPLC-CAD
Polydispersity(Mw/Mn)
Not more than 1.05 GPC
Impurities
Myr-OH Not more than 1.00% HPLC
mPEG-LMG-2K(-28) Not more than 1.00%
HPLC
mPEG-TMG-2K(-14)
Not more than 1.00%
HPLC
mPEG-IMG-2K(+14)
Not more than 1.00%
HPLC
mPEG-PMG-2K(+28)
Not more than 1.00%
HPLC
mPEG-MA-2K Not more than 1.00%
HPLC
mPEG-MG-2K(β) Not more than 1.00% HPLC
mPEG-MG-2K(γ)
Not more than 1.00%
HPLC
Myr-EDU Not more than 1.00%
HPLC
mPEG-DOH-2K Not more than 1.00%
HPLC
TMG Not more than 1.00%
HPLC
EDU Not more than 1000 ppm
HPLC
DMAP Not more than 1000 ppm HPLC
DMG-PEG-DMG-4K Not more than 1.00% GPC
Residual Solvents
Isopropanol Not more than 5000 ppm GC
Dichloromethane Not more than 600 ppm
GC
n-Hexane Not more than 290 ppm
GC
Tetrahydrofuran Not more than 720 ppm
GC
Ethyl Acetate Not more than 5000 ppm
GC
Toluene Not more than 890 ppm
GC
Elemental Impurities
Copper(Cu)
Not more than 30 ppm
ICP-MS
Arsenic(As) Not more than 1.5 ppm
ICP-MS
Chromium(Cr) Not more than 0.2 ppm
ICP-MS
Mercury(Hg) Not more than 0.3 ppm
ICP-MS
Lead(Pb) Not more than 0.5 ppm
ICP-MS
Cobalt(Co) Not more than 0.5 ppm
ICP-MS
Vanadium(V) Not more than 1.0 ppm
ICP-MS
Nickel(Ni)
Not more than 2.0 ppm
ICP-MS
Lithium(Li)
Not more than 25 ppm
ICP-MS
Antimony(Sb)
Not more than 9 ppm ICP-MS
Moisture Not more than 1.00% ChP<0832>
Bacteriological Data
TAMC/g Not more than 100 CFU/g ChP<1105>
TYMC/g
Not more than 10 CFU/g
ChP<1105>
Endotoxin
Not more than 0.015 EU/mg ChP<1143>


Applications:

DMG-PEG 2000 is used for the preparation of liposomes for siRNA delivery, which can improve delivery efficiency. DMG-PEG 2000 can also be used in the preparation of lipid nanoparticles for in vivo delivery of oral plasmid DNA. DMG-PEG 2000 can improve the mucus permeability and delivery efficiency of nanoparticles.



Packaging:

1g/bag, 5g/bag, 10g/bag, 20g/bag, 50g/bag or 100g/bag.



Recommended Storage Conditions:
Kept at -20±5℃ under an inert atmosphere.
To reduce the moisture absorption, it should be slowly warmed to ambient temperature before opened.



Shelf Life:
24 months if stored under above conditions.