Product Name: Vitamin E Polyethylene Glycol Succinate(TPGS)

Alias:TPGS-VE; Tocofersolan; Tocophersolan; tocopherosolan; Vitamin E-TPGS; d-alpha-tocopheryl polyethylene glycol succinate; D-ALPHA-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE

CAS No.: 9002-96-4

Molecular Formula: C33H54O5·(C2H4O)n

Specifications of our D-Alpha-Tocopheryl Polyethylene Glycol Succinate (Vitamin E-TPGS):

Test Items		Specifications	Test Methods
Description		Off-white or yellowish waxy solid	Visual
Identification		Meets the requirements	GC
Assay (D-Alpha-Tocopherol)		Not less than 25.0%	GC
Solubility in water		Not less than 20% (Clear Solution)	USP Method
Acidity		Not more than 0.27mL	USP Method
Specific Rotation		Not less than +24.0°	USP<781S>
Total Heavy Metals		Not more than 10 ppm	USP<231>
Cadmium (Cd)		Not more than 1 ppm	ICP-MS
Arsenic (As)		Not more than 1 ppm	ICP-MS
Lead (Pb)		Not more than 3 ppm	ICP-MS
Mercury (Hg)		Not more than 0.1 ppm	AAS
Residual Solvents		Ethyl Acetate: Not more than 3000 ppm	USP<467>
		Ethanol: Not more than 5000 ppm	USP<467>
Microbial Tests	Total Plate Count	Not more than 1000 CFU/g	USP<61>
	Yeasts & Moulds	Not more than 100 CFU/g	USP<61>
	Salmonella	Negative	USP<61>
	Escherichia coli	Negative	USP<61>

Applications:
Vitamin E polyethylene glycol succinate (TPGS) has been widely used in the research of preparations, as solubilizers, absorption enhancers, emulsifiers, plasticizers, and carriers for poorly water-soluble or fat-soluble drug delivery systems, such as solid dispersions , a carrier for ocular administration, a carrier for intranasal administration, etc. In recent years, many studies have found that in addition to being used as a pharmaceutical excipient, TPGS also has many unique characteristics, such as an absorption enhancer and a multidrug resistance reversal agent, etc. TPGS can also be applied to prodrugs, micelles, liposomes, and TPGS-copolymer carriers to improve the solubility, permeability and stability of preparations, so as to achieve slow, controlled release and targeting, and promote drug absorption.

Packaging:
1kg/bottle, 5kg/bag or according to the specific requirements from customers.

Storage & Transportation:
Preserved in unopened original containers in a cool dry place before using, kept away from direct sunlight, heat and moisture; prevented from rain, strong acids or alkalis. Handle with care during transportation to prevent damage to the packages.

Shelf Life:
36 months if stored under above mentioned conditions.