Product Name: DEXAMETHASONE

Alias: CALONAT; DEXAMETHASON; DEXAMETHASONUM; DEXAMETHASONE BASE; 9-alpha-fluoro-16-alpha-methylprednisolone; (11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE; 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE; (11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione; (8xi,11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

CAS No.: 50-02-2

EINECS No.: 200-003-9

Molecular Formula: C22H29FO5

Molecular Weight: 392.47

Brief Introduction:

Dexamethasone was first synthesized in 1957 and is listed on the World Health Organization's Model List of Essential Medicines. It is one of the essential medicines in the basic public health system. Mainly used as first aid medicine for critical illness and treatment of various types of inflammation. On June 16, 2020, the WHO stated that preliminary clinical trial results in the UK showed that dexamethasone can save the lives of severely ill patients with COVID-19. For patients on ventilators, it can reduce the mortality rate by about one-third; Patients receiving only oxygen reduced their mortality by about a fifth.

Specifications of our DEXAMETHASONE:

Appearance		White or almost white crystalline powder
Identification	A	Meets the requirements
	B	Meets the requirements
Specific Optical Rotation		+86°~ +92° (On the anhydrous basis)
Related Substances	Impurity G	Not more than 0.3%
	Impurity B	Not more than 0.15%
	Impurity F	Not more than 0.15%
	Impurity J	Not more than 0.15%
	Impurity K	Not more than 0.15%
	Unspecified impurity	Not more than 0.10%
	Total impurities	Not more than 0.5%
Loss on Drying		Not more than 0.5%
Assay		97.0% ~ 103.0% (on the anhydrous basis)
Residual Solvents	Methanol	Not more than 3000 ppm
	Acetone	Not more than 5000 ppm
	Methylene Chloride	Not more than 600 ppm

Functions and Uses:

Dexamethasone, like other glucocorticoids, has pharmacological effects such as anti-inflammatory, anti-endotoxin, immune suppression, anti-shock and enhancement of stress response, so it is widely used in various departments to treat a variety of diseases, such as autoimmune diseases, allergies, inflammation, asthma, dermatology, and ophthalmology diseases. Dexamethasone Sodium Phosphate Injection is an indispensable emergency medicine for rescuing critically ill patients. In the past decade, clinicians have used Dexamethasone Sodium Phosphate to treat and prevent drug allergies caused by various Chinese and Western medicines and to treat fever caused by viral colds. disease, the clinical dosage of dexamethasone has increased year by year.

Indications:

Dexamethasone is a long-acting glucocorticoid drug and is a fluorinated derivative of prednisone. It applies to the following situations:
1. Treat various severe infections combined with shock or obvious poisoning symptoms;

2. Reduce intracranial pressure and relieve cerebral edema;

3. Used for the treatment of hypertensive congenital adrenal hyperplasia to inhibit the secretion of pituitary ACTH;

4. Low-dose and high-dose suppression tests can be used to assist in the diagnosis and differential diagnosis of Cushing's syndrome;

5. Anti-inflammatory and anti-allergic, such as active rheumatism, rheumatoid arthritis, systemic lupus erythematosus and other collagen diseases, severe bronchial asthma, dermatitis and other allergic diseases;

6. Can be used to prevent neonatal respiratory distress syndrome;

7. It can reduce the swelling of impacted wisdom teeth extraction wounds;

8. Adhesive sheets can be used for oral mucosal ulcers.

Packaging:
1kg/Aluminum Foil Bag, 5kg/Carton, 10kg/Carton, 25kg/Drum or according to the specific requirements from customers.

Storage Conditions:
Preserved in unopened original containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.

Shelf Life:
24 months if stored under above mentioned conditions.