Product Name: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)

Abbreviation: DPPG-Na

Synonyms: DPPG, Na; DPPG L-5116; 1,2-Dipalmitoyl-sn-glycero-3-PG (sodium salt); 1,2-Dipalmitoyl-sn-glycero-3-phosphorylglycerol sodium salt; 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT; 1,2-Dipalmitoyl-sn-glycero-3-phosphorylglycerol sodium salt (DPPG)

CAS No.: 200880-41-7

Molecular Formula: C73H143Na2O16P

Brief Introduction:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is suitable for the preparation of anionic liposomes, which is a common choice of negatively charged membrane materials and plays a key role in improving the stability of liposomes. It has been widely used in the development of liposome drugs and the prescription of marketed products. It is also used in some liposome projects in the clinical stage, such as cisplatin liposomes Lipoplatin.

Solubility:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can dissolve in water to form salts that can combine with cations (such as Na+).

Surface Active Properties:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) has surface active properties in aqueous solution and can form micelle structures.

Preparation Method:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can be prepared by reacting palmitic acid with glycerol. The specific preparation method is often to first react palmitic acid with a base (such as sodium hydroxide) to form sodium palmitate, and then react with glycerol to form it.

Specifications of our 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt):

Test Items		Specifications
Appearance		This product should be white to off-white powder
Identification	Infrared Spectroscopy	The infrared absorption spectrum of this product should be consistent with that of the reference substance
	Thin-Layer Chromatography	The position and color of the main spots displayed by the test solution should be the same as those of the reference solution.
Related Substances	Impurity A	Not more than 0.5%
	Impurity B	Not more than 0.5%
	Impurity C	Not more than 0.5%
	Other individual impurities	Not more than 0.5%
	The total amount of other impurities	Not more than 1.0%
Free fatty acids		Not more than 0.3%
Purity of palmitic acid		Not less than 98.0%
Water		Not more than 2.0%
Heavy Metals		Not more than 10 ppm
Arsenic (As)		Not more than 0.0002%
Calcium (Ca)		Not more than 0.0250%
Sodium (Na)		Should be between 3.1% and 3.3% (Calculated on the anhydrous basis)
Phosphorus (P)		Should be between 4.1% and 4.3% (Calculated on the anhydrous basis)
Residual Solvents	Acetone	Not more than 0.5%
	Methanol	Not more than 0.3%
	Tetrahydrofuran(THF)	Not more than 0.072%
	Chloroform	Not more than 0.006%
	n-Hexane	Not more than 0.029%
	Acetic Acid	Not more than 0.5%
Bacterial endotoxin		The amount of bacterial endotoxin per 1 mg should be less than 0.3EU
Microbial Limits	The total number of aerobic bacteria	Not more than 1000 CFU/g
	The total number of moulds and yeasts	Not more than 100 CFU/g
	Escherichia coli	Negative/g
Content		Calculated on the anhydrous basis, the content of C38H74NaO10P shall not be less than 98.0%

Applications:

Synthetic phospholipid DPPG-Na is a PG-based synthetic phospholipid, commonly used as liposome membrane material and emulsifier. Specific application examples include cytarabine multivesicular liposomes(Depocyt), morphine sulfate multivesicular liposomes(DepoDur), bupivacaine multivesicular liposomes(Exparel), etc.

Packaging:

1g/bottle, 3g/bottle, 5g/bottle, 10g/bottle, 20g/bottle, 30g/bottle, 50g/bottle or according to the specific requirements from customers.

Recommended Storage Conditions:

Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius. For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Shelf Life:

24 months if stored under above conditions.