Product Name: Cyclopropylboronic acid

Synonyms: AKOS BRN-0457; Cyclopropylboronic; Cyclopropyl boronic acid; Boronic acid, cyclopropyl-; Boronic acid, cyclopropyl- (9CI); Cyclopropylboronic acid,monohydrate; Cyclopropylboronic acid monohydrate; Cyclopropylboronic acid (contains varying amounts of anhydride)

CAS No.: 411235-57-9

EINECS No.: 609-890-0

Molecular Formula: C3H7BO2

Molecular Weight: 85.9

Brief Introduction:

Cyclopropylboronic acid is an organic boronic acid compound. It is a white to light yellow solid at room temperature and pressure, with high thermal stability and solubility. It can be used as an intermediate in organic synthesis and pharmaceutical chemistry, and is widely used in the preparation and derivatization of drug molecules containing cyclopropyl groups. In order to maintain its stability, it needs to be stored and handled in a dry inert atmosphere.

Preparation Methods:

There are many methods for preparing cyclopropylboronic acid, and the common methods include the following:
(1) Reduction of cycloboronic acid: It is prepared by reacting cycloboronic acid with a reducing agent (such as sodium borohydride).
(2) Reaction of cyclopropyllithium with trichloroborane: Cyclopropyllithium is reacted with trichloroborane under an inert atmosphere to obtain cyclopropylboronic acid.

Specifications of our Cyclopropylboronic Acid:

Appearance	White to light yellow solid
Purity (GC)	Not less than 98%
Melting Point	Not less than 90℃
HNMR	Conforms

Applications:

Cyclopropylboronic acid is an important organic synthesis reagent that can react with alkyl halides, acid compounds and alcohols to form the corresponding boric acid esters of aromatic hydrocarbons, alcohols and acids. These reactions are usually catalyzed by palladium catalysts. Cyclopropylboronic acid and its derivatives are widely used in metal organic chemistry, drug synthesis and chemical biology. It can also be used as a chemical synthesis intermediate to prepare various organic compounds, such as aromatic compounds, heterocyclic compounds and drug molecules. In addition, this compound and its derivatives are also used in the field of chemical biology, such as the preparation of fluorescent probes to detect the activity of biological macromolecules.

Packaging:

1kg/Aluminum Foil Bag, 5kg/Carton, 10kg/Carton, 25kg/Fibre Drum or according to the specific requirements from customers.

Storage Conditions:

Store in a sealed unopened container at a temperature ≤ 30°C and a humidity ≤ 75% RH; protect from heat, light and oxygen.

Shelf Life:

12 months if stored under above mentioned conditions.