Product Name: (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid

Abbreviation: tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu

Synonyms: Side chain; Semaglutide side chain; Semaglutide intermediate; tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu; Octadecane(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH; Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioicacid; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid; (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoicacid

CAS No.: 1118767-16-0

Molecular Formula: C43H79N3O13

Molecular Weight: 846.1

Brief Introduction:

The side chain of semaglutide, tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, is a protective group with good solubility and stability. It can protect the amino acid side chains in polypeptides or peptide segments to prevent nonspecific modification or degradation in chemical reactions.

Preparation Method:

Semaglutide side chains can be prepared by synthetic chemical methods. The specific preparation method includes using tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu precursor compounds and synthesizing through appropriate chemical reaction steps. The preparation process requires strict control of reaction conditions and purity to ensure the quality and stability of the product.

Specifications of our tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu:

Test Items		Specifications	Test Methods
Appearance		Off-white or yellowish paste solid	Visual
Identification		Meets the requirements	H-NMR
Purity		Not less than 95.0%	HPLC
e.e. %		Not less than 98.0%	HPLC
Related Substances	tBuO-Iso-Glu(AEEA-AEEA-OH)-OtBu (ZZ-28)	Not more than 0.50%	HPLC
	tBuO-Pal-Glu(AEEA-AEEA-OH)-OtBu (ZZ-23)	Not more than 0.50%	HPLC
	tBuO-Mar-Glu(AEEA-AEEA-OH)-OtBu (ZZ-18)	Not more than 0.50%	HPLC
	tBuO-Non-Glu(AEEA-AEEA-OH)-OtBu (ZZ-13)	Not more than 0.50%	HPLC
	tBuO-Ara-Glu(AEEA-AEEA-OH)-OtBu (ZZ-46)	Not more than 0.50%	HPLC
	tBuO-Ste-Glu(OSu)-OtBu (ZZ-6)	Not more than 0.50%	HPLC
	tBuO-Ste-Glu(AEEA-OH)-OtBu (ZZ-42)	Not more than 0.50%	HPLC
	tBuO-Ste-Glu(AEEA-AEEA-OMe)-OtBu (ZZ-61)	Not more than 1.00%	HPLC
	Sum	Not more than 5.0%	HPLC
Moisture		Not more than 1.00%	Karl Fischer
Volatile Organics	Dichloromethane	Not more than 10000 ppm	GC
	Methyl alcohol	Not more than 5000 ppm	GC
	N-heptane	Not more than 5000 ppm	GC
	Isopropyl alcohol	Not more than 5000 ppm	GC
	n-Hexane	Not more than 290 ppm	GC
Endotoxins		Not more than 2.0 EU/mg	ChP<1143>

Applications:

Semaglutide side chains are widely used in peptide synthesis, especially in peptide fragment synthesis and subsequent functional group modification in solid phase synthesis. By protecting the amino acid side chains, the reaction conditions and selectivity can be effectively controlled and the occurrence of side reactions can be reduced.

Packaging:

1g/bottle, 3g/bottle, 5g/bottle, 10g/bottle, 50g/bottle, 100g/bottle or according to the specific requirements from customers.

Recommended Storage Conditions:

Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius. For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Shelf Life:

36 months if stored under above conditions.