Product Name: Methoxypoly (ethylene glycol) ditetradecylacetamide

Synonyms: ALC-0159; Lipid ALC-0159; Methoxypoly (ethylene glycol) ditetradecylacetamide-2K; 2-(2-methoxyethoxy)-N, N-ditetradecylacetamide, ammonia salt; 2-[(polyethylene glycol)-2000]-N, N ditetradecylacetamide (ALC- 0159); Poly (oxy-1,2-ethanediyl), α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-

Abbreviation: mPEG-DTA-2K

CAS No.: 1849616-42-7

Molecular Mass: 2K, 5K, 10K, 20K, 40K

Brief Introduction:

Methoxypoly(ethylene glycol) ditetradecylacetamide is a pegylated lipid, the CAS number is: 1849616-42-7, which has a unique chemical structure and biological activity. Its structure includes a hydrophilic part and a hydrophobic part, and this dual nature enables it to play a special role in the body.

The introduction of methoxy polyethylene glycol not only increases its solubility in water, but also gives it higher biocompatibility and stability.

The presence of ditetradecyl acetamide gives it good lipophilicity, allowing it to better interact with cell membranes.

Solubility:

Methoxypoly(ethylene glycol) ditetradecylacetamide has good solubility and is soluble in water and many organic solvents.

Test Items		Specifications	Test Methods
Appearance		White powder-like solid	Visual
Identification	IR	Complies with the reference substance structure	IR
	H-NMR	Complies with the reference substance structure	H-NMR
Assay		90.0% ~ 110.0%	HPLC
Purity		Not less than 95.0%	HPLC
Average Molecular Weight		2400±240 Da	MALDI-TOF
Polydispersity(Mw/Mn)		Not more than 1.05	GPC
Related Substances	mPEG-CM-2K	Not more than 1.00%	HPLC
	mPEG-OH-2K	Not more than 1.00%	HPLC
	DTA	Not more than 0.20%	HPLC
	DTA-PEG-DTA-4K	Not more than 1.00%	HPLC
	DTA-PEG-DTA-2K	Not more than 1.00%	HPLC
	mPEG-TA-2K	Not more than 1.00%	HPLC
	mPEG-TTA-2K(-14)	Not more than 1.00%	HPLC
	mPEG-DTA-2K(-28)	Not more than 1.00%	HPLC
	mPEG-TPA-2K(+14)	Not more than 1.00%	HPLC
	mPEG-THA-2K(+28)	Not more than 1.00%	HPLC
	mPEG-THA-2K(+42)	Not more than 1.00%	HPLC
	mPEG-TOA-2K(+56)	Not more than 1.00%	HPLC
	EDU	Not more than 1000 ppm	HPLC
	HOBt	Not more than 1000 ppm	HPLC
Residual Solvents	Dichloromethane	Not more than 600 ppm	GC
	Isopropanol	Not more than 5000 ppm	GC
	n-Hexane	Not more than 290 ppm	GC
	Methyl tert-butyl ether	Not more than 5000 ppm	GC
	Methanol	Not more than 3000 ppm	GC
	Ethanol	Not more than 5000 ppm	GC
	Toluene	Not more than 890 ppm	GC
	Tetrahydrofuran	Not more than 720 ppm	GC
	n-Heptane	Not more than 5000 ppm	GC
Moisture		Not more than 1.00%	KF
Microbial Limits	Total Aerobic Microbial Count	Not more than 100 CFU/g	ChP<1105>
	Total combined Yeasts & Mould Count	Not more than 10 CFU/g	ChP<1105>
Bacterial Endotoxin		Not more than 0.015 EU/mg	ChP<1143>
Elemental Impurities	Cuprum (Cu)	Not more than 30 ppm	ICP-MS
	Arsenic (As)	Not more than 1.5 ppm	ICP-MS
	Cadmium (Cd)	Not more than 0.2 ppm	ICP-MS
	Mercury (Hg)	Not more than 0.3 ppm	ICP-MS
	Lead (Pb)	Not more than 0.5 ppm	ICP-MS
	Cobalt (Co)	Not more than 0.5 ppm	ICP-MS
	Vanadium (V)	Not more than 1.0 ppm	ICP-MS
	Nickel (Ni)	Not more than 2.0 ppm	ICP-MS
	Lithium (Li)	Not more than 25 ppm	ICP-MS
	Antimony (Sb)	Not more than 9 ppm	ICP-MS

Features & Applications of our Methoxypoly(ethylene glycol) ditetradecylacetamide:

In the field of scientific research, Methoxypoly(ethylene glycol) ditetradecylacetamide has received widespread attention due to its unique properties. It has been widely used in drug delivery, cancer research, and biochemistry. As a lipophilic compound, it can effectively encapsulate drugs or other bioactive substances inside to form stable nanoparticles. These nanoparticles can enter the cell through the permeation of the cell membrane to achieve efficient drug delivery.

In addition, Methoxypoly(ethylene glycol) ditetradecylacetamide also has high uptake rate and targeting. It can interact with the cell membrane to promote the cell's uptake of drugs or genetic materials, thereby improving the efficiency of treatment. At the same time, by selecting appropriate targeting ligands, such as antibodies or specific receptor ligands, Methoxypoly(ethylene glycol) ditetradecylacetamide can guide the directional delivery of drugs or genetic materials to target cells or tissues to achieve precise treatment.

It is worth mentioning that Methoxypoly(ethylene glycol) ditetradecylacetamide also shows the advantages of low toxicity and adverse reactions. Compared with the direct use of drugs or genetic materials, the use of methoxypoly(ethylene glycol) ditetradecylacetamide as a delivery system can reduce toxicity and adverse reactions because liposomes can control the release and duration of drugs and reduce damage to normal cells.

Packaging:

1g/Bottle, 3g/Bottle, 5g/Bottle, 10g/Bottle, 50g/Bottle or according to the specific requirements from customers.

Recommended Storage Conditions:

For short-term storage, it is recommended to store at 2℃ ~ 8℃; it is recommended to keep at -25℃ ~ -15℃ under an inert atmosphere for long-term storage.

For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Note:

It should be used in a dry environment and avoided frequent dissolution and freeze-drying.

Shelf Life:

36 months from the date of production if stored in accordance with the above conditions.